Karolin Luger, PhD

Howard Hughes Medical Institute

Department of Biochemistry and Molecular Biology, Colorado State University

Dr. Andrews

Karolin Luger received a B.S. in Microbiology and an M.S. in Biochemistry from the University of Innsbruck in Austria.  She obtained her Ph.D. (summa cum laude) in Biochemistry and Biophysics from the University of Basel in Switzerland, and completed her training as a postdoctoral fellow and research assistant professor at the Swiss Federal Institute of Technology in Zuerich.  She is currently a University Distinguished Professor of Biochemistry and Molecular Biology at Colorado Sate University, and an Investigator for the Howard Hughes Medical Institute.  She has won the Monfort Professor Award and is a Searle Scholar.  In 2013, she was selected as the National Lecturer at the annual Biophysical Society meeting. She is a member of the Keystone Meeting Scientific Advisory Board, and of the Advisory board for the Protein Structure Initiative (PSI).  Luger has served as a member of several NIH study sections. In 2010, she was appointed to the National Advisory General Medical Sciences Council.  This group performs the second level of peer review for research grant applications assigned to NIGMS, and advises the NIH leadership on policy.

Luger was a key player in efforts to elucidate the three-dimensional structure of the nucleosome, the basic repeating unit in chromatin.  Since joining Colorado State University in 1999, she has expanded on this work using a wide range of techniques, such as X-ray crystallography, fluorescence spectroscopy, atomic force microscopy, analytical ultracentrifugation, molecular biology, and in vivo experiments. Her recent work has focused on how histone “chaperones” promote structural changes in chromatin, and how nucleosome dynamics affect gene expression.  She is engaged in numerous national and international collaborations and, together with two other Investigators in the Department of Biochemistry and Molecular Biology is a PI on a collaborative program project grant to investigate histone chaperones and acetyltransferases in chromatin transitions.  


Selected Publications:

Luger, K., Hommel, U., Herold, M., Hofsteenge J. and Kirschner, K. (1989). Correct folding of circularly permuted variants of a beta-alpha barrel enzyme in vivo. Science, 243, 206-210. PMID: 2643160

Luger, K., Mäder, A., Richmond, R.K., Sargent, D. F. and Richmond, T.J. (1997). Structure of the nucleosome core particle at 2.8Å resolution. Nature, 389, 251-260. PMID: 9305837

Suto, R.K., Clarkson, M.J., Tremethick, D.J. and Luger, K. (2000). Crystal Structure of a Nucleosome Core Particle Containing the Variant Histone H2A.Z. Nature Structural Biology, 7, 1121-1124. PMID: 11101893

{C}White, C.L., Suto R.K. and Luger, K. (2001). Structure of the yeast nucleosome core particle reveals fundamental changes in internucleosome interactions. Embo J., 20, 5207-5218. PMID: 11566884

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