Dr. Andrews
 

Patricia K. Donahoe, M.D.

Director, Pediatric Surgical Research Laboratories,
Massachusetts General Hospital

Marshall K. Bartlett Professor of Surgery,
Harvard Medical School, Boston, MA     

 

Dr. Donahoe serves as Director of the Pediatric Surgical Research Laboratories at Massachusetts General Hospital and Marshall K. Bartlett Professor of Surgery at the Harvard Medical School. She is an Associate Member of the Broad Institute, Principle Faculty at the Harvard Stem Cell Institute, and Associate Faculty of the Center for Human Genetics Research. Dr. Donahoe has published over 275 peer-reviewed publications, many in Developmental biology, and holds 12 patents concerning Mullerian Inhibiting Substance (MIS). Her work at the interface of clinical endocrinology in the care and reconstruction of children with intersex anomalies and research in reproductive developmental biology and oncology, led to the hypothesis that MIS could serve as a potential anticancer agent against human ovarian carcinomas and tumors which emanate from the Mullerian duct, such as cervical and endometrial carcinoma. The fact that MIS receptors are expressed in motor neurons is our rational for studying the efficacy of MIS against Amyotrophic Lateral Sclerosis.

Her work is also focused on the genetics of birth defects, particularly Congenital Diaphragmatic Hernia, with the hypothesis that major congenital anomalies are the result of genetic mutations, and the aim that this research will lead to therapies that can be instituted in utero or shortly after birth to alleviate such anomalies or birth defects. Linkage analysis of rare families has been integrated with tissue specific expression and genetic platforms such as whole exomic sequencing and SNP and copy number variants to prioritize potential causative genes. She has trained over 100 fellows who now hold significant academic positions around the world, and is a member of the National Academy of Sciences, the American Academy of Arts and Sciences, and the Institute of Medicine of the National Academy of Sciences. 

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selected publications

Friend WG, Andrews EW, Donahoe PK, Rogers WM. Experimental production of atrial septal defects in dogs.  J Thorac Cardio-Vasc Surg  1965; 50:444-52.

Donahoe PK, Froio RA, Nabseth DC.  Obturator bypass in radical excision of inguinal neoplasm.  Ann Surg 1967; 166:147-9.

Filler RM, Das JB, Haase GM, Donahoe PK.  Muscle surface pH as a monitor of  tissue perfusion and acidbase status.  J Pediatr Surg  1971; 6:536.

Donahoe PK, Hendren WH.  The surgical management of laryngo-tracheoesophageal fistula and esophageal atresia.  Surgery 1972; 71:363-8.

Donahoe PK, Steward DR, Osmond JD, Hendren WH.  Pneumo-peritoneum secondary to pulmonary air leak.  J Pedi 1972; 8:797-800.

Donahoe PK, Osmond JD, Steward DR, Hendren WH.  Renal parencymal tolerance to artery occlusion:  a time and damage study in rats developing collateral circulation.  Ann Surg. 1973; 78:138-42. PMCID: PMC1355621.

Marfatia S, Donahoe PK, Hendren WH.  The effect of dry and humidified gases on the respiratory epithelium.  J Pedi Surg 1975; 10:583-92.

Donahoe PK, Ito Y, Marfatia S, Hendren WH.  The production of Müllerian Inhibiting Substance by fetal, neonatal and adult rat.  Biol Reprod 1976; 15:329-34.

Hendren WH, Donahoe PK, Pfister R. Crossed renal ectopia in children.  Urology 1976; 7:135-44.

Donahoe PK, Hendren WH.  Bile duct perforation in a newborn with stenosis of the ampulla of Vater.  J Pediatr Surg  1976; 11:823-5.

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