Vikram studied Genetics at the University of Georgia and earned his PhD from the University of South Carolina in 2008.
Previous to becoming Evol's Primary Scientist, Vikram worked as a Graduate Student at the University of South Carolina, under Dr. Alan S. Waldman from 2003 to 2008. He then worked as a Postdoctoral Research Associate at Fox Chase Cancer Center in the laboratory of Dr. Tim J. Yen from 2008 to 2014.
He was awarded the Samuel Stroum Fellowship, Pancreatic Cancer Action Network/AACR in 2010-2011 and holds a patent on the Combined Inhibition of the Vitamin D Receptor and DNA Replication in the Treatment of Cancer with Dr. Yen (US 20140163087 A1).
Henry RA, Kuo YM, Bhattacharjee V., Yen TJ, Andrews AJ. Changing the Selectivity of p300 by Acetyl-CoA Modulation of Histone Acetylation. ACS Chem Biol. 2015 Jan 16;10(1):146-56. doi: 10.1021/cb500726b. Epub 2014 Nov 6. PMID: 25325435.
Ganko, E.W., Bhattacharjee, V., Schliekelman, P., McDonald, J.F. Evidence for the contribution of LTR retrotransposons to C. elegans gene evolution. Mol. Biol. Evol. 11:1925-1931, 2003.
Waldman, A.S., Bhattacharjee, V., Waldman, B.C. Effect of hypergravity on intrachromosomal homologous recombination in mammalian cells. FASEB J. 18:C87, 2004.
Ganko, E.W., Greene, C., Lewis, J.A., Bhattacharjee, V., McDonald, J.F. LTR retrotransposon-gene associations in Drosophila melanogaster. J. Mol. Evol. 62:111-120, 2006.
Smith, J.A., Bannister, L.A., Bhattacharjee, V., Wang, Y., Waldman, B.C., Waldman, A.S. Accurate homologous recombination is a prominent double-strand break repair pathway in mammalian chromosomes and is modulated by mismatch repair protein Msh2. Mol. Cell. Biol. 27:7816-7827, 2007. PMCID:PMC2169143
Bhattacharjee, V., Lin, Y., Waldman, B.C., Waldman, A.S. Induction of recombination between diverged sequences in a mammalian genome by a double-strand break. Cell. Mol. Life Sci. 71:2359-2371, 2014. PMCID:PMC24257896
Lal, S., Burkhart, R.A., Bhattacharjee, V., Beeharry, N., Londin, E.R., Cozzitorto, J.A., Kimbo, M., Norris, Z.A., Yeo, C.J., Sawicki, J.A., Rigoutsos, I., Yen, T.J., Brody, J.R. HuR post-transcriptionally regulates WEE1: implications for the DNA damage response in pancreatic cancer cells. Cancer Res. 74:1128-1140, 2014. PMCID:PMC24536047
Bhattacharjee, V., Zhou, Y., Yen, T.J. A synthetic lethal screen identifies VDR as a novel gemcitabine sensitizer in pancreatic cancer cells. Cell Cycle.
10-40-25-BHAT (PI: Bhattacharjee) 7/1/2010 - 6/30/2011
AACR Role: Principal Investigator
Candidate Gene Validation of Sensitizers of Pancreatic Cancer to Gemcitabine
The major goals of this project are: 1) To validate candidate genes for their ability to sensitize cell killing by gemcitabine and 2) To characterize and classify how the validated siRNAs sensitize cell killing by gemcitabine.