Andrew Andrews, PhD
Dr. Andrew Andrews is a scientist with a broad interest in how the environment influences our genetic expression, and how we can use this information to influence our individual gene expression to treat or prevent diseases.
He has developed quantitative assays to reveal both how 6 feet of DNA in the nucleus of our cells is compacted and how enzymes can chemically alter (post-translational modifications) proteins (histones) responsible for this compaction. These post-translational modifications to histones act to both manage gene expression and are of keen interest as possible global markers for major diseases such as cancer, heart disease, and neurological disorders.
A. Andrews, Y. Kuo, R. Henry (2013). Differences in Specificity and Selectivity Between CBP and p300 acetylation of histone H3 and H3/H4
A. Andrews, Y. Kuo (2013). Quantitating the Specificity and Selectivity of Gcn5-Mediated Acetylation of Histone H3, Plos One, The Histone Chaperone Nap1 Promotes Nucleosome Assembly by Eliminating Nonnucleosomal Histone DNA Interactions, Molecular Cell, Volume 37, Issue 6, 834-842, 26 March 2010 Highlights
A. Andrews, Y. Kuo (2008). A Thermodynamic Model for Nap1-Histone Interactions*, The Journal of Biological Chemistry, 283, 32412-32418.